I just had to post this quote. Jobs said it in an address to Stanford University in '05 about a year after he got diagnosed with cancer. This guy almost literally worked until his death, and the last 7 years have been spent battling cancer. He was an awesome guy.
"Remembering that I'll be dead soon is the most important tool I've ever encountered to help me make the big choices in life. Because almost everything — all external expectations, all pride, all fear of embarrassment or failure - these things just fall away in the face of death, leaving only what is truly important. Remembering that you are going to die is the best way I know to avoid the trap of thinking you have something to lose. You are already naked. There is no reason not to follow your heart."
-Steve Jobs