oblivion is one of those games that a macro makes soo much easier.
Here are the ones I think will be needed from day one. I will probably use my Oblivion Macros and just tweak them a bit for Skyrim...
Run Forward - On a Tac (Run forward without having to push up on the stick)
Sell one item at a time - On a Tac (used to raise mercentile if that is a skill in Skyim)
Cast Training Spells - On a Tac (would have different spell or weapon in each hand and fire them back and forth)